Better known as the web-slinging Spider-Man, Miles reteams with Gwen Stacey a.k.a. Spider-Woman to fight a dangerous foe. As the pair learn of a supervillain with multi-dimensional powers, they must warn all Spider-People across different universes of the oncoming threat. In the process the pair meet the Spider-Force, sworn protectors of the multiverse who have their own ideas of how to deal with the menace.